Pique Therapeutics recently announced positive results for its lead immunotherapy (PT 107) from its Phase 2 clinical trial in patients with late-stage, second-line non-small cell lung cancer (NSCLC). The Company was founded on research licensed from the University of Miami and discovered by the late Eckhard R. Podack, M.D., Ph.D., one of the pioneering researchers in the field of immunotherapy. Dr. Podack was the discoverer of perforin-1 and perforin-2, and also created the technology underlying brentuximab (Adcetris®), used in the treatment of Hodgkin lymphoma.

Pique's lead product, PT 107, is a first-in-class allogeneic whole cell vaccine for the treatment of non-small cell lung cancer. In a previous Phase 1 trial, PT 107 was shown to induce robust cytolytic T cells that persisted for more than two years, was well tolerated, and exhibited a very good safety profile in cancer patients. In this trial, PT 107 showed a dramatic improvement in median overall survival for patients with second-line, late-stage non-small cell lung cancer, more than doubling the expected survival in these patients. Remarkably, over 30% of PT 107-treated patients survived 4 years or longer.